Scientific Reports (Feb 2021)

Potential impact of a nonavalent anti HPV vaccine in Italian men with and without clinical manifestations

  • Liana Bosco,
  • Nicola Serra,
  • Teresa Fasciana,
  • Daniela Pistoia,
  • Marco Vella,
  • Leonardo Di Gregorio,
  • Rosaria Schillaci,
  • Antonino Perino,
  • Gloria Calagna,
  • Alberto Firenze,
  • Giuseppina Capra

DOI
https://doi.org/10.1038/s41598-021-83639-6
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

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Abstract Human papilloma virus infection (HPV) is the most common sexually transmitted disease. Little is known about male infection. Nonavalent vaccine against types 6/11/16/18/31/33/45/52/58 was approved and neutral gender immunization programs have been proposed. This study evaluates the potential impact of nonavalent vaccine compared to quadrivalent in male living in Sicily (Italy). 58.7% of samples were HPV positive and forty-four types of HPV were identified. A significant higher estimated coverage of nonavalent vaccine than quadrivalent was observed (64.3% vs. 45.8%), with absolute and relative additional impact of 20.1% and 47.2%, respectively. Low impact of the vaccine were calculated as the empirical probability of HPV genotypes 6/11/16/18/31/33/45/52/58 alone or in combination; the high impact as empirical probability of HPV6/11/16/18/31/33/45/52/58 genotypes alone or in association with other genotypes. The potential impact of the nonavalent vaccine vs quadrivalent was significant for low and high impact (29.7% > 18:8%; 34:6% > 26.6%, respectively). Particularly, in men with lesions and risky sexual contact was significant only for low impact (35.5% > 29.7%; 31.4% > 19.7%, respectively). In partners with positive females was significant for low impact (26.3% > 15.1%) and high impact (33.7% > 23.2%). Nonavalent vaccine offers broader protection in men with HPV positive partners, who would have a potential role in the transmission of the infection.