Spontaneous Isomerization of Long-Lived Proteins Provides a Molecular Mechanism for the Lysosomal Failure Observed in Alzheimer’s Disease

• Tyler R. Lambeth,
• Dylan L. Riggs,
• Lance E. Talbert,
• Jin Tang,
• Emily Coburn,
• Amrik S. Kang,
• Jessica Noll,
• Catherine Augello,
• Byron D. Ford,
• Ryan R. Julian

Affiliations

Tyler R. Lambeth

Department of Chemistry, University of California, Riverside, California, United States

Dylan L. Riggs

Department of Chemistry, University of California, Riverside, California, United States

Lance E. Talbert

Department of Chemistry, University of California, Riverside, California, United States

Jin Tang

Department of Chemistry, University of California, Riverside, California, United States

Emily Coburn

Department of Chemistry, University of California, Riverside, California, United States

Amrik S. Kang

Department of Chemistry, University of California, Riverside, California, United States

Jessica Noll

Division of Biomedical Sciences, University of California, Riverside, California, United States

Catherine Augello

Division of Biomedical Sciences, University of California, Riverside, California, United States

Byron D. Ford

Division of Biomedical Sciences, University of California, Riverside, California, United States

Ryan R. Julian

Department of Chemistry, University of California, Riverside, California, United States