Frontiers in Medicine (Apr 2021)

Case Report: CD8+ T-Lymphocyte Deficit: A Prerequisite for Pasteurella spp. Infection?

  • Eric Denes,
  • Fabrice Fiorenza,
  • Mateo Armendariz,
  • Christian Martin

DOI
https://doi.org/10.3389/fmed.2021.668976
Journal volume & issue
Vol. 8

Abstract

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Background: Immunity against Pasteurella spp. is not well-known for humans.Methods: We've tested T CD8+ lymphocytes in a patient with a chronic prosthetic joint infection due to Pasteurella spp. to search for a deficit which could have favored her infection. As this deficit was found, we've searched for such a deficit in other patients with Pasteurella spp. Infections, either acute or subacute.Results: Eight patients were tested and all had a persistent T CD8+ lymphocytes deficit. This is striking as these cells are involved in the response to this type of infection in animal models.Conclusion: The authors suggest that a deficit in CD8+ T lymphocytes can be one of the causes for the onset of infections with P. multocida.

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