Nature Communications (Feb 2019)

Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis

  • Daniel L. Hess,
  • Molly R. Kelly-Goss,
  • Olga A. Cherepanova,
  • Anh T. Nguyen,
  • Richard A. Baylis,
  • Svyatoslav Tkachenko,
  • Brian H. Annex,
  • Shayn M. Peirce,
  • Gary K. Owens

DOI
https://doi.org/10.1038/s41467-019-08811-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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Perivascular cells are essential to the formation and stabilization of new blood vessels during angiogenesis. Here, Hess and Kelly-Goss et al. show that the stem cell pluripotency factor Oct4 promotes perivascular cell survival and migration required for angiogenesis in contexts of tissue injury and hypoxia.