Nature Communications (Feb 2019)
Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis
Abstract
Perivascular cells are essential to the formation and stabilization of new blood vessels during angiogenesis. Here, Hess and Kelly-Goss et al. show that the stem cell pluripotency factor Oct4 promotes perivascular cell survival and migration required for angiogenesis in contexts of tissue injury and hypoxia.