Frontiers in Oncology (Feb 2022)

Case Report: Hematologic Recovery Following Stereotactic Ablative Radiotherapy in a Patient With Early-Stage Non-Small Cell Lung Cancer and Paraneoplastic Myelofibrosis

  • Lindsey Sloan,
  • Lindsey Sloan,
  • Rakhi P. Naik,
  • Kavita Umrau,
  • Rena Ruiyu Xian,
  • Kristen A. Marrone,
  • Khinh Ranh Voong

DOI
https://doi.org/10.3389/fonc.2022.842620
Journal volume & issue
Vol. 12

Abstract

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Herein, we report the first case presentation of paraneoplastic myelofibrosis associated with cancer. Paraneoplastic syndromes occur in some patients with thoracic malignancies; however, myelofibrosis is not commonly seen in non-small cell lung cancer (NSCLC). We report a case of myelofibrosis in a patient with a new diagnosis of NSCLC that resolved after stereotactic ablative radiotherapy (SABR). In conclusion, NSCLC may evoke unexpected systemic effects that resolve with treatment.

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