Endocrine Regulations (Jan 2023)

GHRL, LEP, LEPR genes polymorphism and their association with the metabolic syndrome in the Ukrainian population

  • Prodan Andrii,
  • Dzubanovsky Ihor,
  • Kamyshnyi Oleksandr,
  • Melnyk Natalia,
  • Pidruchna Svitlana,
  • Voloshyn Stanislava

DOI
https://doi.org/10.2478/enr-2023-0030
Journal volume & issue
Vol. 57, no. 1
pp. 269 – 278

Abstract

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Objective. Many conflicting results have been obtained in the study of leptin (LEP) and leptin receptor (LEPR) gene variants that are associated with the obesity and diabetes possibly due to differences in the study populations. The aim of this study was to evaluate changes in the metabolic hormones (leptin, ghrelin, adiponectin, resistin) levels in the blood of obese patients in relation to the GHRL (rs696217), LEP (rs7799039), LEPR (rs1137100, rs1137101, rs1805094) polymorphism in Ukrainian population.

Keywords