The report describes the local and regional geological factors of the South Yakutia, through which it is planned to build a gas pipeline. On this territory there are the main karstic rocks, with relatively high mineral solubilities: dolomite, limestone and gypsum. These rocks have different dissolution rates and others geological settings. The assessment of the karst holes diameters for the gas pipeline section was made. The measures to protect potentially hazardous sections are suggested, including timely notification about sinkholes.