Nature Communications (Jan 2021)
DsbA-L deficiency in T cells promotes diet-induced thermogenesis through suppressing IFN-γ production
- Haiyan Zhou,
- Xinyi Peng,
- Jie Hu,
- Liwen Wang,
- Hairong Luo,
- Junyan Zhang,
- Yacheng Zhang,
- Guobao Li,
- Yujiao Ji,
- Jingjing Zhang,
- Juli Bai,
- Meilian Liu,
- Zhiguang Zhou,
- Feng Liu
Affiliations
- Haiyan Zhou
- National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University
- Xinyi Peng
- National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University
- Jie Hu
- National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University
- Liwen Wang
- National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University
- Hairong Luo
- National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University
- Junyan Zhang
- National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University
- Yacheng Zhang
- National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University
- Guobao Li
- National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University
- Yujiao Ji
- National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University
- Jingjing Zhang
- National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University
- Juli Bai
- Department of Pharmacology, University of Texas Health Science Center at San Antonio
- Meilian Liu
- Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center
- Zhiguang Zhou
- National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University
- Feng Liu
- National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University
- DOI
- https://doi.org/10.1038/s41467-020-20665-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Adipose tissue-resident T cells are known to regulate thermogenesis and energy expenditure. Here the authors report that deletion of mitochondria-localized protein DsbA-L in T cells promotes diet-induced thermogenesis via suppressing IFN-γ production.
