A dietary fatty acid counteracts neuronal mechanical sensitization

Luis O. Romero; Rebeca Caires; Alec R. Nickolls; Alexander T. Chesler; Julio F. Cordero-Morales; Valeria Vásquez

doi:10.1038/s41467-020-16816-2

Nature Communications (Jun 2020)

A dietary fatty acid counteracts neuronal mechanical sensitization

Luis O. Romero,
Rebeca Caires,
Alec R. Nickolls,
Alexander T. Chesler,
Julio F. Cordero-Morales,
Valeria Vásquez

Affiliations

Luis O. Romero: 71S. Manassas St. Department of Physiology, College of Medicine, University of Tennessee Health Science Center
Rebeca Caires: 71S. Manassas St. Department of Physiology, College of Medicine, University of Tennessee Health Science Center
Alec R. Nickolls: National Center for Complementary and Integrative Health, National Institutes of Health
Alexander T. Chesler: National Center for Complementary and Integrative Health, National Institutes of Health
Julio F. Cordero-Morales: 71S. Manassas St. Department of Physiology, College of Medicine, University of Tennessee Health Science Center
Valeria Vásquez: 71S. Manassas St. Department of Physiology, College of Medicine, University of Tennessee Health Science Center

DOI: https://doi.org/10.1038/s41467-020-16816-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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PIEZO2 is a critical component of the mechanism by which innocuous touch causes pain (tactile allodynia). Here, authors find that the dietary fatty acid margaric acid decreases PIEZO2 function in a dose-dependent manner and counteracts neuronal mechanical sensitization by a proalgesic agent.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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