Facile and Convenient Synthesis of New Thieno[2,3-b]-Thiophene Derivatives

Abstract

A facile and convenient synthesis of bis(2-(1H-benzo[d]imidazol-2(3H)-ylidene)-3-oxopropanenitrile), bis((3-amino-5-(methylthio)-1H-pyrazol-4-yl)methanone) and bis(2-thioxo-1,2-dihydropyrimidine-5-carbonitrile) derivatives incorporating a thieno- [2,3-b]thiophene moiety via versatile, readily accessible diethyl 3,4-dimethylthieno-[2,3-b]thiophene-2,5-dicarboxylate (1) is described.

Keywords

• thieno[2,3-b]thiophene
• bis-heterocycles
• nucleophilic addition
• 2-bromo-1-phenylethanone