Association of COL1A1 gene -1997 C>A (rs1107946) polymorphism with bone mineral density in postmenopausal women

Abstract

Objective: to study bone mineral density indexes in zone of L1-L4 lumbar vertebrae and left and right femur proximal departments including left and right femoral necks in postmenopausal women according to genotypes of -1997 C>A polymorphism of COL1A1 gene. Materials and methods: 483 Caucasian women from eastern and central regions of Ukraine were examined. All women were postmenopausal. Osteodensitometry was carried out by dual-energy X-ray absorptiometry method. Detection of a gene COL1A1 -1997 C>A polymorphism was carried out by the real-time PCR method. Results: it was established that the low bone mineral density indicators in zone of left femoral neck were associated with AA genotype (Р=0,040), and in zone of right femoral neck and proximal department – with AA and CA genotypes (Р=0,008-P=0,035). Association of polymorphic variations of COL1A1 gene (-1997 C>A) with mineral density of L1-L4 lumbar vertebrae was not established. Conclusion: the obtained data can be used for detection of predisposition to postmenopausal osteoporosis development and increase of treatment-and-prophylactic actions effectiveness.

Keywords

• col1a1 gene
• -1997 c>a polymorphism
• osteoporosis
• women
• postmenopause