Nature Communications (Apr 2023)

Predicting response to enzalutamide and abiraterone in metastatic prostate cancer using whole-omics machine learning

  • Anouk C. de Jong,
  • Alexandra Danyi,
  • Job van Riet,
  • Ronald de Wit,
  • Martin Sjöström,
  • Felix Feng,
  • Jeroen de Ridder,
  • Martijn P. Lolkema

DOI
https://doi.org/10.1038/s41467-023-37647-x
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 19

Abstract

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Prostate cancer is known to have a variable response to androgen receptor signalling inhibitors. Here, the authors use machine learning to predict response to therapy from genomic, transcriptomic and clinical data.