IMMUNOLOGICAL MECHANISMS OF APOPTOSIS IN PLACENTAL DEVELOPMENT

Medicinskaâ Immunologiâ. 2008;10(2-3):125-138 DOI 10.15789/1563-0625-2008-2-3-125-138

 

Journal Homepage

Journal Title: Medicinskaâ Immunologiâ

ISSN: 1563-0625 (Print); 2313-741X (Online)

Publisher: SPb RAACI

Society/Institution: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists

LCC Subject Category: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy

Country of publisher: Russian Federation

Language of fulltext: Russian

Full-text formats available: PDF

 

AUTHORS

D. I. Sokolov (ГУ НИИ акушерства и гинекологии им. Д.О. Отта РАМН, Санкт-Петербург)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 12 weeks

 

Abstract | Full Text

Abstract. In present review, the data are considered that concern a role of immunological mechanisms controlling the events of apoptosis at different stages of development of placenta. Intensity of apoptotic process in human placenta is progressively increasing in the course of pregnancy, until delivery act. The processes of apoptosis induction and its prevention in placental cells are inseparably linked to development of placenta and formation of vascular system, as controlled by trophoblast cells, as well as by maternal fetal immune cells. T-lymphocytes, natural killer cells, NKT-cells and macrophages that perform surveillance over the processes of angiogenesis and apoptosis in placental tissue, thus providing its normal development and functioning.