Nature Communications (Mar 2018)
A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset
- Willy Chin,
- Guansheng Zhong,
- Qinqin Pu,
- Chuan Yang,
- Weiyang Lou,
- Paola Florez De Sessions,
- Balamurugan Periaswamy,
- Ashlynn Lee,
- Zhen Chang Liang,
- Xin Ding,
- Shujun Gao,
- Collins Wenhan Chu,
- Simone Bianco,
- Chang Bao,
- Yen Wah Tong,
- Weimin Fan,
- Min Wu,
- James L. Hedrick,
- Yi Yan Yang
Affiliations
- Willy Chin
- Institute of Bioengineering and Nanotechnology
- Guansheng Zhong
- State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University
- Qinqin Pu
- Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota
- Chuan Yang
- Institute of Bioengineering and Nanotechnology
- Weiyang Lou
- State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University
- Paola Florez De Sessions
- Genome Institute of Singapore
- Balamurugan Periaswamy
- Genome Institute of Singapore
- Ashlynn Lee
- Institute of Bioengineering and Nanotechnology
- Zhen Chang Liang
- Institute of Bioengineering and Nanotechnology
- Xin Ding
- Institute of Bioengineering and Nanotechnology
- Shujun Gao
- Institute of Bioengineering and Nanotechnology
- Collins Wenhan Chu
- Genome Institute of Singapore
- Simone Bianco
- IBM Almaden Research Center
- Chang Bao
- State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University
- Yen Wah Tong
- Department of Chemical and Biomolecular Engineering, National University of Singapore
- Weimin Fan
- State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University
- Min Wu
- Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota
- James L. Hedrick
- IBM Almaden Research Center
- Yi Yan Yang
- Institute of Bioengineering and Nanotechnology
- DOI
- https://doi.org/10.1038/s41467-018-03325-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Antibiotic resistance is a major threat across the whole healthcare spectrum. Here, the authors report on the development of biodegradable guanidinium functionalized polycarbonates and demonstrate antimicrobial activity against drug resistant infections.
