Role of integrins in the development of fibrosis in the trabecular meshwork

Jennifer A. Faralli; Mark S. Filla; Donna M. Peters; Donna M. Peters

doi:10.3389/fopht.2023.1274797

Frontiers in Ophthalmology (Oct 2023)

Role of integrins in the development of fibrosis in the trabecular meshwork

Jennifer A. Faralli,
Mark S. Filla,
Donna M. Peters,
Donna M. Peters

Affiliations

Jennifer A. Faralli: Department of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States
Mark S. Filla: Department of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States
Donna M. Peters: Department of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States
Donna M. Peters: Department of Ophthalmology & Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States

DOI: https://doi.org/10.3389/fopht.2023.1274797
Journal volume & issue: Vol. 3

Abstract

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Primary open angle glaucoma (POAG) is a progressive and chronic disease exhibiting many of the features of fibrosis. The extracellular matrix (ECM) in the trabecular meshwork (TM) undergoes extensive remodeling and enhanced rigidity, resembling fibrotic changes. In addition, there are changes associated with myofibroblast activation and cell contractility that further drives tissue fibrosis and stiffening. This review discusses what is known about the integrins in the TM and their involvement in fibrotic processes.

Published in Frontiers in Ophthalmology

ISSN: 2674-0826 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine
Website: https://www.frontiersin.org/journals/ophthalmology

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Abstract

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