Study of Acute and Chronic Antihyperglycemic Activity of Methanolic Extract of Salvia mirzayanii Rech. & Esfand. in Rats

Abstract

Background: In folk medicine, there are many uses of useful effects of some medicinal plants for treatment of disease. In traditional medicine of Kerman province, Salvia mirzayanii Rech. & Esfand. (Lamiaceae) or Mor-e-Porzo applies for treatment of diabetes mellitus. Literature reviews showed another species of Salvia had antidiabetic effects. Objective: In this study anti hyperglycemic activities of this plant were evaluated. Methods: Eleven group (n=7) of male white rats (six normal and five diabetic) used. Diabetes induced by IP injection of streptozocin (STZ) (64 mg/kg). Diabetes was allowed to develop in these STZ treated rat over of 24h, and animals treated by 50, 100, 200, 400 mg/kg of the dried metanolic extract by IP injection for 24 hours and 400 mg/kg for 12 days. Finally, surgery carried out on these animals and liver and pancreas studied histopathologically. For statistic, used ANOVA with Turkeyschr('39') post hoc. Results: The maximal reduction in the blood glucose concentration of the fasted rats occurred at extract 400 mg/kg dose of extract. This dose (400 mg/kg) significantly reduced the blood glucose concentrations (p<0.01). On the other hand, histopathological studies showed this extract could repair and increase blood supply of pancreatic cells of these diabetic animals. Conclusion: Methanolic extract of S. mirzayanii could reduce blood glucose of these diabetic animals and its considerable effects on damaged pancreatic tissue, persuade the complemented studies and investigation on this plant.

Keywords

• salvia mirzayanii
• diabetes
• streptozocin
• rat
• methanolic extract