Scintigraphy assessment of ischemic myocardial viability in patients with post-infarction left ventricular aneurysm

Abstract

The study included 15patients with coronary heart disease (CHD), post-infarction cardiosclerosis, and chronic left ventricular (LV) aneurysm. All patients underwent interventional myocardial revascularization and Dor aneurysmectomy. Myocardial scintigraphy with 99mTc-MYOVIEW was performed at baseline (during nitroglycerine test and at rest), and 3-4 weeks after revascularization (at rest). According to baseline scintigraphy at rest data, 35 % of the segments were hypoperfused, and in 20 % the agent did not accumulate. After sublingual nitroglycerine administration, hypo- and non-perfused segment percentage reduced to 24 % and 11 %, respectively, after revascularization - to 24 % and 11 %. Single-photon emission computed tomography with 99mTc-MYOVIEW, combined with sublingual nitroglycerin test, identifies viable myocardial zones in post-infarction LV aneurism area and might be used for predicting post-revascularization LV function recovery.

Keywords

• myocardial perfusion
• hibernation
• viability
• coronary heart disease
• nitroglycerin