JACC: Advances (Dec 2024)
Spontaneous Coronary Artery Dissection
- Daniela Crousillat, MD,
- Amy Sarma, MD,
- Malissa Wood, MD,
- Sahar Naderi, MD, MHS,
- Katherine Leon, MS,
- C Michael Gibson, MD,
- Aaron Aday, MD, MSc,
- Anna Grodzinsky, MD, MS,
- Kathy Izard, BA,
- Jason C. Kovacic, MD, PhD,
- Mark E. Lindsay, MD, PhD,
- Dermot Phelan, MD, PhD,
- Patricia F. Rodriguez-Lozano, MD, MS,
- Nandita S. Scott, MD,
- Markus Scherer, MD,
- Aditya Sharma, MD,
- Ranya Sweis, MD,
- Jennifer A. Sumner, PhD,
- Esther S.H. Kim, MD, MPH
Affiliations
- Daniela Crousillat, MD
- Division of Cardiovascular Sciences, Department of Medicine and Obstetrics and Gynecology, University of South Florida Morsani College of Medicine, Tampa General Hospital Heart and Vascular Institute, Tampa, Florida, USA
- Amy Sarma, MD
- Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA
- Malissa Wood, MD
- Division- Heart Institute, Lee Health Heart Institute, Fort Myers, Florida, USA
- Sahar Naderi, MD, MHS
- Division of Cardiology, Kaiser Permanente Northern California, San Francisco, California, USA
- Katherine Leon, MS
- SCAD Alliance, Alexandria, Virginia, USA
- C Michael Gibson, MD
- PERFUSE Study Group, Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
- Aaron Aday, MD, MSc
- Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, Tennessee, USA
- Anna Grodzinsky, MD, MS
- Saint Luke’s Mid America Heart Institute/University of Missouri-Kansas City, Kansas City, Missouri, USA
- Kathy Izard, BA
- SCAD Alliance, Alexandria, Virginia, USA
- Jason C. Kovacic, MD, PhD
- Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Vascular Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia; St. Vincent's Clinical School, University of NSW, Sydney, New South Wales, Australia
- Mark E. Lindsay, MD, PhD
- Cardiovascular Genetics Program, Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA
- Dermot Phelan, MD, PhD
- Gragg Center for Cardiovascular Performance, Sanger Heart & Vascular Institute, Atrium Health, Charlotte, North Carolina, USA
- Patricia F. Rodriguez-Lozano, MD, MS
- Cardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, Virginia, USA
- Nandita S. Scott, MD
- Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
- Markus Scherer, MD
- Sanger Heart and Vascular Institute, Atrium Health, Charlotte, North Carolina, USA
- Aditya Sharma, MD
- Division of Cardiovascular Medicine, University of Virginia, Charlottesville, Virginia, USA
- Ranya Sweis, MD
- Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
- Jennifer A. Sumner, PhD
- Department of Psychology, University of California, Los Angeles, California, USA
- Esther S.H. Kim, MD, MPH
- Sanger Heart & Vascular Institute, Atrium Health, Charlotte, North Carolina, USA; Address for correspondence: Dr Esther S.H. Kim, Atrium Health, 1237 Harding Place, Suite 2300, Charlotte, North Carolina 28204, USA.
- Journal volume & issue
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Vol. 3,
no. 12
p. 101385
Abstract
Despite marked advancements in the recognition and diagnosis of spontaneous coronary artery dissection (SCAD) over the past decade, knowledge of the basic pathophysiologic mechanisms of disease, contributing factors, and treatment continue to be poorly understood. We describe significant research gaps in our knowledge of SCAD and introduce strategies including the role of patient advocacy, independent registries, and creation of diverse centers of excellence to bridge the gap in clinical care, research, and outcomes. Lastly, we introduce an innovative patient-centered clinical care and research framework established through the SCAD Alliance and International Spontaneous Coronary Artery Dissection registry as a model for advancing knowledge of SCAD.
