Role of Vaginal Microbiota Dysbiosis in Gynecological Diseases and the Potential Interventions

Yiwen Han; Yiwen Han; Zhaoxia Liu; Tingtao Chen; Tingtao Chen

doi:10.3389/fmicb.2021.643422

Frontiers in Microbiology (Jun 2021)

Role of Vaginal Microbiota Dysbiosis in Gynecological Diseases and the Potential Interventions

Yiwen Han,
Yiwen Han,
Zhaoxia Liu,
Tingtao Chen,
Tingtao Chen

Affiliations

Yiwen Han: Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang, China
Yiwen Han: Queen Mary School, Nanchang University, Nanchang, China
Zhaoxia Liu: Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang, China
Tingtao Chen: Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang, China
Tingtao Chen: National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, China

DOI: https://doi.org/10.3389/fmicb.2021.643422
Journal volume & issue: Vol. 12

Abstract

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Vaginal microbiota dysbiosis, characterized by the loss of Lactobacillus dominance and increase of microbial diversity, is closely related to gynecological diseases; thus, intervention on microbiota composition is significant and promising in the treatment of gynecological diseases. Currently, antibiotics and/or probiotics are the mainstay of treatment, which show favorable therapeutic effects but also bring problems such as drug resistance and high recurrence. In this review, we discuss the role of vaginal microbiota dysbiosis in various gynecological infectious and non-infectious diseases, as well as the current and potential interventions.

Published in Frontiers in Microbiology

ISSN: 1664-302X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/journals/microbiology

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Abstract

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