Three-dimensional structural dynamics of DNA origami Bennett linkages using individual-particle electron tomography

Dongsheng Lei; Alexander E. Marras; Jianfang Liu; Chao-Min Huang; Lifeng Zhou; Carlos E. Castro; Hai-Jun Su; Gang Ren

doi:10.1038/s41467-018-03018-0

Nature Communications (Feb 2018)

Three-dimensional structural dynamics of DNA origami Bennett linkages using individual-particle electron tomography

Dongsheng Lei,
Alexander E. Marras,
Jianfang Liu,
Chao-Min Huang,
Lifeng Zhou,
Carlos E. Castro,
Hai-Jun Su,
Gang Ren

Affiliations

Dongsheng Lei: The Molecular Foundry, Lawrence Berkeley National Laboratory
Alexander E. Marras: Department of Mechanical and Aerospace Engineering, The Ohio State University
Jianfang Liu: The Molecular Foundry, Lawrence Berkeley National Laboratory
Chao-Min Huang: Department of Mechanical and Aerospace Engineering, The Ohio State University
Lifeng Zhou: Department of Mechanical and Aerospace Engineering, The Ohio State University
Carlos E. Castro: Department of Mechanical and Aerospace Engineering, The Ohio State University
Hai-Jun Su: Department of Mechanical and Aerospace Engineering, The Ohio State University
Gang Ren: The Molecular Foundry, Lawrence Berkeley National Laboratory

DOI: https://doi.org/10.1038/s41467-018-03018-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 8

Abstract

Read online

Scaffolded DNA origami by folding single-stranded DNA into three-dimensional nanostructures holds promise for building functional nanomachines, yet their dynamic structures remain largely unknown. Here, Lei et al. address this issue using individual-particle electron tomography at 6–14 nm resolution.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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