Nature Communications (Nov 2019)

A multi-sample approach increases the accuracy of transcript assembly

  • Li Song,
  • Sarven Sabunciyan,
  • Guangyu Yang,
  • Liliana Florea

DOI
https://doi.org/10.1038/s41467-019-12990-0
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 7

Abstract

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Transcript assembly is an important step in analysis of RNA-seq data whose accuracy influences downstream quantification, detection and characterization of alternative splice variants. Here, the authors develop PsiCLASS, a transcript assembler leveraging simultaneous analysis of multiple RNA-seq samples.