Scientific Reports (Jan 2021)

Mortality trends in an ambulatory multidisciplinary heart failure unit from 2001 to 2018

  • Giosafat Spitaleri,
  • Josep Lupón,
  • Mar Domingo,
  • Evelyn Santiago-Vacas,
  • Pau Codina,
  • Elisabet Zamora,
  • Germán Cediel,
  • Javier Santesmases,
  • Crisanto Diez-Quevedo,
  • Maria Isabel Troya,
  • Maria Boldo,
  • Salvador Altmir,
  • Nuria Alonso,
  • Beatriz González,
  • Julio Núñez,
  • Antoni Bayes-Genis

DOI
https://doi.org/10.1038/s41598-020-79926-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

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Abstract To assess mortality trends at 1 and 3 years from 2001 to 2018 in a real-life cohort of HF outpatients from different etiologies with depressed and preserved LVEF. A total of 2368 consecutive patients with HF (mean age 66.4 ± 12.9 years, 71% men, 15.4% with preserved LVEF) admitted to a HF clinic from August 2001 to September 2018 were included in the study. Patients were divided into five quintiles (Q) according to the period of admission. Trends for all-cause and cardiovascular mortality from Q1 to Q5 were assessed by linear regression. Patients with LVEF < 50% had a progressive decrease in the rates of all-cause and cardiovascular death at 1 year (12.1% in Q1 to 6.5% in Q5, p = 0.003; and 8.4% in Q1 to 3.8% in Q5, p = 0.007, respectively) and 3 years (30.5% in Q1 to 17.0% in Q5, p = 0.003; and 23.9% in Q1 to 9.8% in Q5, p = 0.003, respectively). These trends remained significant after adjusting for clinical characteristics and risk. No significant trend in mortality was observed in patients with LVEF ≥ 50%. In a cohort of real-life ambulatory patients with HF, mortality progressively declined in patients with LVEF < 50%, but the same trend was not observed in patients with preserved LVEF.