INHERITANCE OF POLYMORPHIC GENOTYPES OF THE ENDOTHELIN-1 GENE AND INDICATORS OF CARDIAC AND SYSTEMIC HEMODYNAMICS IN MEN WITH ESSENTIAL HYPERTENSION, RESIDENTS OF PODILLYA

Abstract

The parameters of intracardiac and systemic hemodynamics in male citizens of Podillia region in Ukraine aged 40-60 with different genotypes of the ET-1 gene were studied. The study involved 141 male citizens of Podillia region in Ukraine aged 40-60. Among them 62 men were diagnosed with uncomplicated EH with LVH, whose average age was 49,19±0,66 and 79 healthy men whose age (49.01±0.73) did not differ from patients with uncomplicated EH with LVH and made the control group (p>0.05). Genotyping of the ET-1 gene was conducted using polymerase chain reaction. The ET-1 concentration in plasma was determined by using ELISA. It was found that Lys/Lys genotype and the Lys allele of the ET-1 gene dominate among control group and patients with uncomplicated EH and LVH. In patients with uncomplicated EH and LVH all indicators of structural-functional state of the myocardium, except the size of LA, SI, DT was significantly greater in carriers of the allele Asn, than in homozygote carriers of Lys genotype of the ET-1 gene, indicating a possible negative prognosis in these patients for the development of chronic heart failure. CHLV occurs significantly more often than EHLV in men with uncomplicated EH and LVH without dependence on the genotypes of the ET-1 gene.

Keywords

• essential hypertension, gene polymorphism of endothelin-1, cardiac and systemic hemodynamics, plasma concentration of endothelin-1