Lychee seed polyphenol ameliorates DR via inhibiting inflammasome/apoptosis and angiogenesis in hRECs and db/db mice

Xiao-Hong Xiang; Jing Wei; Xiao-Fang Wang; Qin Xu; Chong-Lin Yu; Chang-Long He; Tao Long; Ming-Song Guo; Xue Chen; Xiao-Gang Zhou; Jian-Ming Wu; Da-Lian Qin; An-Guo Wu; Yong Tang; Hong-Bin Lv

Biomedicine & Pharmacotherapy (Nov 2023)

Lychee seed polyphenol ameliorates DR via inhibiting inflammasome/apoptosis and angiogenesis in hRECs and db/db mice

Xiao-Hong Xiang,
Jing Wei,
Xiao-Fang Wang,
Qin Xu,
Chong-Lin Yu,
Chang-Long He,
Tao Long,
Ming-Song Guo,
Xue Chen,
Xiao-Gang Zhou,
Jian-Ming Wu,
Da-Lian Qin,
An-Guo Wu,
Yong Tang,
Hong-Bin Lv

Affiliations

Xiao-Hong Xiang: Department of Ophthalmology in the Affiliated Hospital of Southwest Medical University, Luzhou, China
Jing Wei: Department of Ophthalmology in the Affiliated Hospital of Southwest Medical University, Luzhou, China; Eye School and Key Laboratory of Sichuan Province Ophthalmopathy Prevention & Cure and Visual Function Protection of Chengdu University of TCM, Chengdu, China
Xiao-Fang Wang: Department of Human Anatomy School of Preclinical Medicine Southwest Medical University, Luzhou, China
Qin Xu: Department of Ophthalmology in the Affiliated Hospital of Southwest Medical University, Luzhou, China
Chong-Lin Yu: Department of Human Anatomy School of Preclinical Medicine Southwest Medical University, Luzhou, China
Chang-Long He: Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica of Southwest Medical University, Luzhou, China
Tao Long: Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica of Southwest Medical University, Luzhou, China
Ming-Song Guo: Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica of Southwest Medical University, Luzhou, China
Xue Chen: Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica of Southwest Medical University, Luzhou, China
Xiao-Gang Zhou: Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica of Southwest Medical University, Luzhou, China
Jian-Ming Wu: Department of Human Anatomy School of Preclinical Medicine Southwest Medical University, Luzhou, China
Da-Lian Qin: Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica of Southwest Medical University, Luzhou, China
An-Guo Wu: Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica of Southwest Medical University, Luzhou, China; Corresponding authors.
Yong Tang: Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica of Southwest Medical University, Luzhou, China; State Key Laboratory of Quality Research in Chinese Medicine of Macau University of Science and Technology, Macau, China; Corresponding author at: Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica of Southwest Medical University, Luzhou, China.
Hong-Bin Lv: Department of Ophthalmology in the Affiliated Hospital of Southwest Medical University, Luzhou, China; Corresponding authors.

Journal volume & issue: Vol. 167
p. 115478

Abstract

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Blood retinal barrier (BRB) damage is an important pathogenesis of diabetic retinopathy, and alleviating BRB damage has become a key target for DR treatment. We previously found that Lycopene seed polyphenols (LSP) maintained BRB integrity by inhibiting NLRP3 inflammasome-mediated inflammation. However, it is still unknown whether LSP inhibits retinal neovascularization with abnormal capillaries and its mechanism of action. Here, we employed db/db mice and hRECs to find that LSP increases the level of glycolipid metabolism, maintains the morphology of retinal endothelial cells and inhibits acellular capillary neogenesis. Mechanistic studies revealed that LSP inhibits the NLRP3 inflammasome, reduces cell apoptosis in retinal tissue, increases tight junction protein (TJ) expression, and reduces vascular endothelial growth factor (VEGF) and Ve-Cadherin in vivo and in vitro. Collectively, this study finds that LSP inhibits inflammation and angiogenesis to improve BRB function to ameliorate DR.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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