Nature Communications (Apr 2022)
In vivo imaging of invasive aspergillosis with 18F-fluorodeoxysorbitol positron emission tomography
- Dong-Yeon Kim,
- Ayoung Pyo,
- Sehyeon Ji,
- Sung-Hwan You,
- Seong Eun Kim,
- Daejin Lim,
- Heejung Kim,
- Kyung-Hwa Lee,
- Se-Jeong Oh,
- Ye-rim Jung,
- Uh Jin Kim,
- Subin Jeon,
- Seong Young Kwon,
- Sae-Ryung Kang,
- Hyang Burm Lee,
- Hoon Hyun,
- So-Young Kim,
- Kyung-Sub Moon,
- Sunwoo Lee,
- Seung Ji Kang,
- Jung-Joon Min
Affiliations
- Dong-Yeon Kim
- College of Pharmacy and Research Institute of Pharmaceutical Science, Gyeongsang National University
- Ayoung Pyo
- Innovation Center for Molecular Probe Development, Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital
- Sehyeon Ji
- Department of Internal Medicine, Chonnam National University Medical School
- Sung-Hwan You
- CNCure Biotech
- Seong Eun Kim
- Department of Internal Medicine, Chonnam National University Medical School
- Daejin Lim
- Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University
- Heejung Kim
- Korea Radioisotope Center for Pharmaceuticals, Korea Institute of Radiological & Medical Sciences
- Kyung-Hwa Lee
- Department of Pathology, Chonnam National University Medical School
- Se-Jeong Oh
- Department of Neurosurgery, Chonnam National University Medical School
- Ye-rim Jung
- Innovation Center for Molecular Probe Development, Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital
- Uh Jin Kim
- Department of Internal Medicine, Chonnam National University Medical School
- Subin Jeon
- Innovation Center for Molecular Probe Development, Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital
- Seong Young Kwon
- Innovation Center for Molecular Probe Development, Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital
- Sae-Ryung Kang
- Innovation Center for Molecular Probe Development, Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital
- Hyang Burm Lee
- Department of Agricultural Biological Chemistry, Chonnam National University
- Hoon Hyun
- Department of Biomedical Sciences, Chonnam National University Medical School
- So-Young Kim
- CNCure Biotech
- Kyung-Sub Moon
- Department of Neurosurgery, Chonnam National University Medical School
- Sunwoo Lee
- Department of Chemistry, Chonnam National University
- Seung Ji Kang
- Department of Internal Medicine, Chonnam National University Medical School
- Jung-Joon Min
- CNCure Biotech
- DOI
- https://doi.org/10.1038/s41467-022-29553-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Current diagnostic methods for invasive aspergillosis are time-consuming and poorly sensitive. Here, the authors show that positron emission tomography with 2-deoxy-2-18F-fluorosorbitol can visualize Aspergillus fumigatus infection of the lungs, brain and muscles in mouse models, and can distinguish pulmonary aspergillosis from other diseases such as Staphylococcus aureus infection and lung cancer.
