High Pretreatment Mean Corpuscular Volume Can Predict Worse Prognosis in Patients With Esophageal Squamous Cell Carcinoma who Have Undergone Curative Esophagectomy

Naoya Yoshida, MD, PhD; Ken Sasaki, MD, PhD; Kengo Kanetaka, MD, PhD; Yasue Kimura, MD, PhD; Tomotaka Shibata, MD, PhD; Makoto Ikenoue, MD; Yuichiro Nakashima, MD, PhD; Noriaki Sadanaga, MD, PhD; Kojiro Eto, MD, PhD; Yusuke Tsuruda, MD; Shinichiro Kobayashi, MD, PhD; Tomonori Nakanoko, MD, PhD; Kosuke Suzuki, MD, PhD; Shinsuke Takeno, MD, PhD; Manabu Yamamoto, MD, PhD; Masaru Morita, MD, PhD; Yasushi Toh, MD, PhD; Hideo Baba, MD, PhD

doi:10.1097/AS9.0000000000000165

Annals of Surgery Open (Jun 2022)

High Pretreatment Mean Corpuscular Volume Can Predict Worse Prognosis in Patients With Esophageal Squamous Cell Carcinoma who Have Undergone Curative Esophagectomy

Naoya Yoshida, MD, PhD,
Ken Sasaki, MD, PhD,
Kengo Kanetaka, MD, PhD,
Yasue Kimura, MD, PhD,
Tomotaka Shibata, MD, PhD,
Makoto Ikenoue, MD,
Yuichiro Nakashima, MD, PhD,
Noriaki Sadanaga, MD, PhD,
Kojiro Eto, MD, PhD,
Yusuke Tsuruda, MD,
Shinichiro Kobayashi, MD, PhD,
Tomonori Nakanoko, MD, PhD,
Kosuke Suzuki, MD, PhD,
Shinsuke Takeno, MD, PhD,
Manabu Yamamoto, MD, PhD,
Masaru Morita, MD, PhD,
Yasushi Toh, MD, PhD,
Hideo Baba, MD, PhD

Affiliations

Naoya Yoshida, MD, PhD: From the * Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Chuoku, Kumamoto, Japan
Ken Sasaki, MD, PhD: † Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima-shi, Kagoshima, Japan
Kengo Kanetaka, MD, PhD: ‡ Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Yasue Kimura, MD, PhD: § Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
Tomotaka Shibata, MD, PhD: ∥ Department of Gastroenterological and Pediatric Surgery, Oita University, Hasama, Oita, Japan
Makoto Ikenoue, MD: ¶ Division of Gastrointestinal-Endocrine-Pediatric Surgery, Department of Surgery, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan
Yuichiro Nakashima, MD, PhD: # Department of Gastroenterological Surgery, National Hospital Organization, Kyushu Cancer Center, Miniami-ku, Fukuoka, Japan
Noriaki Sadanaga, MD, PhD: ** Department of Surgery, Saiseikai Fukuoka General Hospital, Chuo-ku, Fukuoka, Japan.
Kojiro Eto, MD, PhD: From the * Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Chuoku, Kumamoto, Japan
Yusuke Tsuruda, MD: † Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima-shi, Kagoshima, Japan
Shinichiro Kobayashi, MD, PhD: ‡ Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Tomonori Nakanoko, MD, PhD: § Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
Kosuke Suzuki, MD, PhD: ∥ Department of Gastroenterological and Pediatric Surgery, Oita University, Hasama, Oita, Japan
Shinsuke Takeno, MD, PhD: ¶ Division of Gastrointestinal-Endocrine-Pediatric Surgery, Department of Surgery, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan
Manabu Yamamoto, MD, PhD: # Department of Gastroenterological Surgery, National Hospital Organization, Kyushu Cancer Center, Miniami-ku, Fukuoka, Japan
Masaru Morita, MD, PhD: # Department of Gastroenterological Surgery, National Hospital Organization, Kyushu Cancer Center, Miniami-ku, Fukuoka, Japan
Yasushi Toh, MD, PhD: # Department of Gastroenterological Surgery, National Hospital Organization, Kyushu Cancer Center, Miniami-ku, Fukuoka, Japan
Hideo Baba, MD, PhD: From the * Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Chuoku, Kumamoto, Japan

DOI: https://doi.org/10.1097/AS9.0000000000000165
Journal volume & issue: Vol. 3, no. 2
p. e165

Abstract

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Objective:. To establish the prognostic value of mean corpuscular volume (MCV) in patients with esophageal squamous cell carcinoma (ESCC) who have undergone esophagectomy. Background:. The MCV increases in patients with high alcohol and tobacco consumption. Such a lifestyle can be a risk factor for malnutrition, comorbidities related to those habits, and multiple primary malignancies, which may be associated with frequent postoperative morbidity and poor prognosis. Methods:. This study included 1673 patients with ESCC who underwent curative esophagectomy at eight institutes between April 2005 and November 2020. Patients were divided into normal and high MCV groups according to the standard value of their pretreatment MCV. Clinical background, short-term outcomes, and prognosis were retrospectively compared between the groups. Results:. Overall, 26.9% of patients had a high MCV, which was significantly associated with male sex, habitual smoking and drinking, multiple primary malignancies, and malnutrition, as estimated by the body mass index, hemoglobin and serum albumin values, and the Geriatric Nutritional Risk Index. Postoperative respiratory morbidity (P = 0.0075) frequently occurred in the high MCV group. A high MCV was an independent prognostic factor for worse overall survival (hazard ratio, 1.27; 95% confidence interval, 1.049–1.533; P = 0.014) and relapse-free survival (hazard ratio, 1.23; 95% confidence interval, 1.047–1.455; P = 0.012). Conclusions:. A high MCV correlates with habitual drinking and smoking, malnutrition, and multiple primary malignancies and could be a surrogate marker of worse short-term and long-term outcomes in patients with ESCC who undergo esophagectomy.

Published in Annals of Surgery Open

ISSN: 2691-3593 (Online)
Publisher: Wolters Kluwer Health
Country of publisher: United States
LCC subjects: Medicine: Surgery
Website: https://journals.lww.com/aosopen/pages/default.aspx

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