Histone variant H2A.B-H2B dimers are spontaneously exchanged with canonical H2A-H2B in the nucleosome

Rina Hirano; Yasuhiro Arimura; Tomoya Kujirai; Mikihiro Shibata; Aya Okuda; Ken Morishima; Rintaro Inoue; Masaaki Sugiyama; Hitoshi Kurumizaka

doi:10.1038/s42003-021-01707-z

Communications Biology (Feb 2021)

Histone variant H2A.B-H2B dimers are spontaneously exchanged with canonical H2A-H2B in the nucleosome

Rina Hirano,
Yasuhiro Arimura,
Tomoya Kujirai,
Mikihiro Shibata,
Aya Okuda,
Ken Morishima,
Rintaro Inoue,
Masaaki Sugiyama,
Hitoshi Kurumizaka

Affiliations

Rina Hirano: Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo
Yasuhiro Arimura: Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo
Tomoya Kujirai: Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo
Mikihiro Shibata: Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi
Aya Okuda: Institute for Integrated Radiation and Nuclear Science (KURNS), Kyoto University
Ken Morishima: Institute for Integrated Radiation and Nuclear Science (KURNS), Kyoto University
Rintaro Inoue: Institute for Integrated Radiation and Nuclear Science (KURNS), Kyoto University
Masaaki Sugiyama: Institute for Integrated Radiation and Nuclear Science (KURNS), Kyoto University
Hitoshi Kurumizaka: Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo

DOI: https://doi.org/10.1038/s42003-021-01707-z
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 11

Abstract

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Hirano et al. show that the H2A.B-H2B histone dimer incorporated within the nucleosome exchanges with the canonical H2A-H2B dimer without assistance from histone chaperones or nucleosome remodelers. This study provides insights into how the H2A.B nucleosome exchanges its histones.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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