Determination of Enantiomeric Excess by Solid-Phase Extraction Using a Chiral Metal-Organic Framework as Sorbent

Abstract

Metal-organic frameworks (MOFs) have recently attracted considerable attention because of their fascinating structures and intriguing potential applications in diverse areas. In this study, we developed a novel method for determination of enantiomeric excess (ee) of (±)-1,1′-bi-2-naphthol by solid-phase extraction (SPE) using a chiral MOF, [Co(l-tyr)]n(l-tyrCo), as sorbent. After optimization of the experimental conditions, a good linear relationship between the ee and the absorbance of the eluate (R2 = 0.9984) was obtained and the standard curve was established at the concentration of 3 mmol L−1. The ee values of (±)-1,1′-bi-2-naphthol samples can be rapidly calculated using the standard curve after determination of the absorbance of the eluate. The method showed good accuracy, with an average error of 2.26%, and is promising for ee analysis.

Keywords

• metal-organic frameworks
• enantiomeric excess
• chiral compounds
• solid-phase extraction