Targeting ITK signaling for T cell-mediated diseases
Samuel Weeks,
Rebecca Harris,
Mobin Karimi
Affiliations
Samuel Weeks
Department of Microbiology and Immunology, SUNY Upstate Medical University, 766 Irving Avenue Weiskotten Hall Suite 2281, Syracuse, NY 13210, USA
Rebecca Harris
Department of Microbiology and Immunology, SUNY Upstate Medical University, 766 Irving Avenue Weiskotten Hall Suite 2281, Syracuse, NY 13210, USA
Mobin Karimi
Department of Microbiology and Immunology, SUNY Upstate Medical University, 766 Irving Avenue Weiskotten Hall Suite 2281, Syracuse, NY 13210, USA; Corresponding author
Summary: The focus of this review is to examine the role of ITK signaling in multiple diseases and investigate the clinical potential of ITK inhibition. The diseases and potential interventions reviewed include T cell-derived malignancies as well as other neoplastic diseases, allergic diseases such as asthma and atopic dermatitis, certain infectious diseases, several autoimmune disorders such as rheumatoid arthritis and psoriasis, and finally the use of ITK inhibition in both solid organ and bone marrow transplantation recipients.
