Nature Communications (Oct 2020)

Evolution of DNA replication origin specification and gene silencing mechanisms

  • Y. Hu,
  • A. Tareen,
  • Y-J. Sheu,
  • W. T. Ireland,
  • C. Speck,
  • H. Li,
  • L. Joshua-Tor,
  • J. B. Kinney,
  • B. Stillman

DOI
https://doi.org/10.1038/s41467-020-18964-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Contrary to most eukaryotes that lack sequence-specific origins of replication, S. cerevisiae origins are defined by specific DNA sequence motifs. Here the authors reveal that multiple subunits of ORC, including Orc2 and Orc4, contribute to the sequence-specificity of origins in S. cerevisiae.