Nature Communications (Feb 2016)
Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns
- Bonnie R. Joubert,
- Herman T. den Dekker,
- Janine F. Felix,
- Jon Bohlin,
- Symen Ligthart,
- Emma Beckett,
- Henning Tiemeier,
- Joyce B. van Meurs,
- Andre G. Uitterlinden,
- Albert Hofman,
- Siri E. Håberg,
- Sarah E. Reese,
- Marjolein J. Peters,
- Bettina Kulle Andreassen,
- Eric A. P. Steegers,
- Roy M. Nilsen,
- Stein E. Vollset,
- Øivind Midttun,
- Per M. Ueland,
- Oscar H. Franco,
- Abbas Dehghan,
- Johan C. de Jongste,
- Michael C. Wu,
- Tianyuan Wang,
- Shyamal D. Peddada,
- Vincent W. V. Jaddoe,
- Wenche Nystad,
- Liesbeth Duijts,
- Stephanie J. London
Affiliations
- Bonnie R. Joubert
- Division of Intramural Research, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health
- Herman T. den Dekker
- The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
- Janine F. Felix
- The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
- Jon Bohlin
- Norwegian Institute of Public Health
- Symen Ligthart
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Emma Beckett
- Department of Applied Sciences, School of Environmental and Life Sciences, University of Newcastle
- Henning Tiemeier
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Joyce B. van Meurs
- Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam
- Andre G. Uitterlinden
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Albert Hofman
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Siri E. Håberg
- Norwegian Institute of Public Health
- Sarah E. Reese
- Division of Intramural Research, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health
- Marjolein J. Peters
- Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam
- Bettina Kulle Andreassen
- Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo
- Eric A. P. Steegers
- Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Center Rotterdam
- Roy M. Nilsen
- Department of Research and Development, Centre for Clinical Research, Haukeland University Hospital
- Stein E. Vollset
- Norwegian Institute of Public Health
- Øivind Midttun
- Bevital A/S, Laboratoriebygget
- Per M. Ueland
- Department of Clinical Science, University of Bergen
- Oscar H. Franco
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Abbas Dehghan
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Johan C. de Jongste
- Department of Pediatrics, Division of Respiratory Medicine, Erasmus MC, University Medical Center Rotterdam
- Michael C. Wu
- Public Health Sciences Program, Fred Hutchinson Cancer Research Center
- Tianyuan Wang
- Division of Intramural Research, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health
- Shyamal D. Peddada
- Division of Intramural Research, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health
- Vincent W. V. Jaddoe
- The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
- Wenche Nystad
- Norwegian Institute of Public Health
- Liesbeth Duijts
- The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
- Stephanie J. London
- Division of Intramural Research, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health
- DOI
- https://doi.org/10.1038/ncomms10577
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 8
Abstract
Folic acid is routinely recommended for women trying to conceive to ensure proper fetal development. Here, the authors perform a large epigenomics study to examine which fetal epigenetic changes are associated with varied maternal plasma folate levels.
