Sensing intracellular calcium ions using a manganese-based MRI contrast agent

Ali Barandov; Benjamin B. Bartelle; Catherine G. Williamson; Emily S. Loucks; Stephen J. Lippard; Alan Jasanoff

doi:10.1038/s41467-019-08558-7

Nature Communications (Feb 2019)

Sensing intracellular calcium ions using a manganese-based MRI contrast agent

Ali Barandov,
Benjamin B. Bartelle,
Catherine G. Williamson,
Emily S. Loucks,
Stephen J. Lippard,
Alan Jasanoff

Affiliations

Ali Barandov: Department of Biological Engineering, Massachusetts Institute of Technology
Benjamin B. Bartelle: Department of Biological Engineering, Massachusetts Institute of Technology
Catherine G. Williamson: Department of Biological Engineering, Massachusetts Institute of Technology
Emily S. Loucks: Department of Biological Engineering, Massachusetts Institute of Technology
Stephen J. Lippard: Department of Chemistry, Massachusetts Institute of Technology
Alan Jasanoff: Department of Biological Engineering, Massachusetts Institute of Technology

DOI: https://doi.org/10.1038/s41467-019-08558-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

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There are only few MRI-compatible calcium reporters and they are limited to measuring extracellular calcium levels. Here the authors develop and validate a cell-permeable, manganese-based paramagnetic MRI contrast agent that enables monitoring intracellular calcium signals in vivo in the rat brain.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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