A case of pelvic squamous cell carcinoma of unknown primary origin that responded well to radiotherapy and nivolumab

Hiroaki Koge, MD; Ayako Hino, MD, PhD; Akira Kakiuchi, MD; Yayoi Yamamoto, MD, PhD; Akira Kanbe, MD; Daichi Kojima, MD; Ayumi Horikawa, MD, PhD; Tsunehiro Doiuchi, MD; Hiroaki Kurihara, MD, PhD

Radiology Case Reports (May 2024)

A case of pelvic squamous cell carcinoma of unknown primary origin that responded well to radiotherapy and nivolumab

Hiroaki Koge, MD,
Ayako Hino, MD, PhD,
Akira Kakiuchi, MD,
Yayoi Yamamoto, MD, PhD,
Akira Kanbe, MD,
Daichi Kojima, MD,
Ayumi Horikawa, MD, PhD,
Tsunehiro Doiuchi, MD,
Hiroaki Kurihara, MD, PhD

Affiliations

Hiroaki Koge, MD: Department of Diagnostic and Interventional Radiology, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa, 2410815, Japan
Ayako Hino, MD, PhD: Corresponding author.; Department of Diagnostic and Interventional Radiology, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa, 2410815, Japan
Akira Kakiuchi, MD: Department of Diagnostic and Interventional Radiology, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa, 2410815, Japan
Yayoi Yamamoto, MD, PhD: Department of Diagnostic and Interventional Radiology, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa, 2410815, Japan
Akira Kanbe, MD: Department of Diagnostic and Interventional Radiology, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa, 2410815, Japan
Daichi Kojima, MD: Department of Diagnostic and Interventional Radiology, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa, 2410815, Japan
Ayumi Horikawa, MD, PhD: Department of Diagnostic and Interventional Radiology, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa, 2410815, Japan
Tsunehiro Doiuchi, MD: Department of Diagnostic and Interventional Radiology, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa, 2410815, Japan
Hiroaki Kurihara, MD, PhD: Department of Diagnostic and Interventional Radiology, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa, 2410815, Japan

Journal volume & issue: Vol. 19, no. 5
pp. 1881 – 1885

Abstract

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Squamous cell carcinoma of unknown primary origin in the pelvis is rare. We report a case of a 64-year-old woman with a large osteolytic squamous cell carcinoma of unknown primary origin in the pelvis that presented with p16 expression. The patient presented with leg pain and swelling and was admitted to our hospital. Computed tomography scans of the pelvis revealed a large osteolytic tumor. A computed tomography-guided needle biopsy was performed, and pathological examination revealed neoplastic cells with metastatic squamous cell carcinoma presenting with p16 expression. Despite a whole-body examination, tumor origin remained undetected. The patient was treated for this metastatic squamous cell carcinoma of unknown primary using palliative radiotherapy for hip pain and nivolumab. Remarkable reduction in the tumor marker levels and tumor size were obtained after therapy. Finally, partial remission and progression-free survival for more than 7 months were achieved. In conclusion, we experienced a rare case with a large p16-positive squamous cell carcinoma of unknown primary in pelvis, which responded well to radiotherapy and nivolumab.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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