Monoclonal Antibodies production technology

Abstract

Since the first cells were capable of maintain a continuous antibody supply, developed by Köhler and Milstein in 1975, its use in medicine and industry showed a great potential. New researches were developed to enhance the use of such cells, including immunizations, mieloma cells, fusion methodology, screening techniques, cloning, culture media, among several details which enable and optimizes its use. Nowadays, monoclonal antibodies are a well-established tool for proteomics research and it have countless applications on several knowledge areas, mainly human and/or animal disease diagnostic, identification and tracking of allergenic compounds in food and residues in the environment. This review can be used by professionals, researches and students searching for a compiled papers contributing to the improvement of the monoclonal antibodies technology, used at different knowledge areas such as human diseases and diseases and disorders in agriculture and livestock chain.

Keywords

• antígeno-anticorpo
• imunoensaios
• soro