Evaluation of Levels of Serum IgE and Rectal Mucosal Eosinophilia in Irritable Bowel Syndrome

Abstract

INTRODUCTION[|]Irritable bowel syndrome (IBS) and food allergic reactions are common in the community and can cause symptoms similar to each other. In this study, it is aimed to evaluate serum immunglobulin E (IgE) and rectum mucosal eosinophilia levels in IBS.[¤]METHODS[|]Record of patients who applied between April 2013 and April 2014 were retrospectively screened and patients who were 18–70 years old and previously performed rectal biopsy by colonoscopy and diagnosed with IBS according to Rome III criteria were included in the study. All patients were grouped as diarrheal dominant IBS (IBS-D), constipation dominant IBS (IBS-C), mix type IBS (IBS-M) and unclassified IBS (IBS-U) according to their symptoms. In addition, serum IgE levels and rectal mucosal eosinophilia levels were evaluated from all patients' records.[¤]RESULTS[|]39 (56.52%) of total 69 patients with IBS were in the IBS-C group, 19 (27.54%) of them were in the IBS-D, 9 (13.04%) of them were in the IBS-M and 2 (2.90%) of them were in the IBS-U. There were not any significant differences between IBS subgroups in terms of presence of allergic disease and presence of food allergy (p=0.519 and p=0.849, respectively). The median level of rectal eosinophilia in IBS subgroups was found to be 2.00 (0.00 to 88.00) in IBS-C subgroup, 5.00 (0.00–100.00) in IBS-D subgroup and 2.00 (0.00 to 11.00) in IBS-M subgroup. In addition, IgE levels were found high in 7 (19.45%) of IBS-C subgroup, 7 (36.84%) of IBS-D subgroup and 3 (33.33%) of IBS-M group (p=0.348).[¤]DISCUSSION AND CONCLUSION[|]In this study, relation between serum IgE and rectal eosinophilia levels with IBS subgroups could not not found.[¤]

Keywords

• abdominal pain
• defecation
• diarrhea
• irritable bowel syndrome