Association between the rs3812316 Single Nucleotide Variant of the <i>MLXIPL</i> Gene and Alpha-Linolenic Acid Intake with Triglycerides in Mexican Mestizo Women

Abstract

The carbohydrate response element binding protein (ChREBP) is a key transcription factor to understand the gene–diet–nutrient relationship that leads to metabolic diseases. We aimed to analyze the association between the rs17145750 and rs3812316 SNVs (single nucleotide variants) of the MLXIPL gene with dietary, anthropometric, and biochemical variables in Mexican Mestizo subjects. This is a cross-sectional study of 587 individuals. Genotyping was performed by allelic discrimination. In addition, liver and adipose tissue biopsies were obtained from a subgroup of 24 subjects to analyze the expression of the MLXIPL gene. An in silico test of the protein stability and allelic imbalance showed that rs17145750 and rs3812316 showed a high rate of joint heritability in a highly conserved area. The G allele of rs3812316 was associated with lower triglyceride levels (OR = −0.070 ± 0.027, p p < 0.001).

Keywords

• G dyslipidemias
• triglycerides
• MLXIPL
• ChREBP
• alpha-linolenic acid
• omega-3