Advances in polysaccharide-based probiotic delivery systems: A review

Abstract

Probiotics have a positive effect on improving the balance of gut microbes, enhancing immune function, and reducing the symptoms of chronic diseases. However, the survival and stability of probiotics in the gastrointestinal tract is limited. Many methods have been developed to solve this problem; micro-nanoparticle delivery is an effective new approach. Polysaccharide-based delivery systems have received much attention and research in drug delivery. However, the application in the delivery of probiotics is substantially less than that in the delivery of drugs. The aim of this study was to highlight the important application and potential of polysaccharides in micro-nano delivery systems. By investigating the application in drug delivery, the potential for application in probiotic delivery was discussed. The application prospects of polysaccharides in anti-oxidant, anti-inflammatory, and immune regulation were demonstrated. The advantages of combining probiotics with polysaccharide microparticles were summarized, and future research directions are proposed, including the optimization of particle encapsulation technology, clinical trial validation, and the exploration of further applications in the food and biomedical industries.

Keywords

• probiotics
• microparticles
• nanoparticles
• polysaccharides
• encapsulation
• delivery system