JACS Au (Oct 2024)
Pyrimidine Azepine Targets the Plasmodium bc1 Complex and Displays Multistage Antimalarial Activity
- Juliana Calit,
- Surendra K. Prajapati,
- Ernest D. Benavente,
- Jessica E. Araújo,
- Bingbing Deng,
- Kazutoyo Miura,
- Yasmin Annunciato,
- Igor M. R. Moura,
- Miho Usui,
- Jansen F. Medeiros,
- Carolina H. Andrade,
- Sabrina Silva-Mendonça,
- Anton Simeonov,
- Richard T. Eastman,
- Carole A. Long,
- Maisa da Silva Araujo,
- Kim C. Williamson,
- Anna Caroline C. Aguiar,
- Daniel Y. Bargieri
Affiliations
- Juliana Calit
- Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil
- Surendra K. Prajapati
- Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States
- Ernest D. Benavente
- Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands
- Jessica E. Araújo
- Plataforma de Produção e Infecção de Vetores da Malária−PIVEM, Laboratório de Entomologia, Fundação Oswaldo Cruz-Fiocruz Rondônia, Porto Velho, RO, Brazil
- Bingbing Deng
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States
- Kazutoyo Miura
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States
- Yasmin Annunciato
- Department of Bioscience, Federal University of São Paulo, São Paulo, SP, Brazil
- Igor M. R. Moura
- Institute of Physics of São Carlos, University of São Paulo, São Carlos, SP, Brazil
- Miho Usui
- Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States
- Jansen F. Medeiros
- Plataforma de Produção e Infecção de Vetores da Malária−PIVEM, Laboratório de Entomologia, Fundação Oswaldo Cruz-Fiocruz Rondônia, Porto Velho, RO, Brazil
- Carolina H. Andrade
- LabMol−Laboratory for Molecular Modeling and Drug Design−Faculty of Pharmacy, Federal University of Goias, Goiania, GO, Brazil
- Sabrina Silva-Mendonça
- LabMol−Laboratory for Molecular Modeling and Drug Design−Faculty of Pharmacy, Federal University of Goias, Goiania, GO, Brazil
- Anton Simeonov
- Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States
- Richard T. Eastman
- Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States
- Carole A. Long
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States
- Maisa da Silva Araujo
- Plataforma de Produção e Infecção de Vetores da Malária−PIVEM, Laboratório de Entomologia, Fundação Oswaldo Cruz-Fiocruz Rondônia, Porto Velho, RO, Brazil
- Kim C. Williamson
- Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States
- Anna Caroline C. Aguiar
- Department of Bioscience, Federal University of São Paulo, São Paulo, SP, Brazil
- Daniel Y. Bargieri
- Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil
- DOI
- https://doi.org/10.1021/jacsau.4c00674
- Journal volume & issue
-
Vol. 4,
no. 10
pp. 3942 – 3952
Abstract
No abstracts available.
