Breast Cancer: Targets and Therapy (Oct 2019)

Cryoablation In The Management Of Breast Cancer: Evidence To Date

  • Pusceddu C,
  • Paliogiannis P,
  • Nigri G,
  • Fancellu A

Journal volume & issue
Vol. Volume 11
pp. 283 – 292

Abstract

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Claudio Pusceddu,1 Panagiotis Paliogiannis,2 Giuseppe Nigri,3 Alessandro Fancellu4 1Division of Interventional Radiology, Department of Oncologic Radiology, Businco Hospital, Cagliari, Italy; 2Unit of Experimental Pathology and Oncology, Department of Medical Surgical and Experimental Sciences, University of Sassari, Sassari, Italy; 3Department of Medical and Surgical Sciences and Translational Medicine, Sapienza University of Rome, St. Andrea University Hospital, Rome, Italy; 4Unit of General Surgery 2 - Clinica Chirurgica, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, ItalyCorrespondence: Alessandro FancelluUniversity of Sassari, Department of Medical, Surgical and Experimental Sciences, Unit of General Surgery 2 - Clinica Chirurgica, V.le San Pietro 43, Sassari 07100, ItalyTel +39 079 228432Fax +39 079 228394Email [email protected]: Cryoablation has been successfully used to treat various type of solid tumors, including breast carcinomas. This ablation method has the advantage of being a minimally invasive procedure useful in various clinical situations, including early breast cancer and metastatic breast cancer, when co-morbidities preclude the use of surgical treatment. However, due to the small sample size of the available studies, reliable and definitive conclusions on the usefulness of cryoablation in patients with breast cancer could not be drawn. In fact, many aspects necessitate to be elucidated, regarding technical issues, indications, efficacy, imaging follow-up, and possible advantages over other percutaneous ablative methods. This review article has the aim to clarify the current evidence supporting cryoablation of breast cancer, and discuss the future perspectives, including those arising from the new studies on immunological effects related to cryoablation.Keywords: cryoablation, breast cancer, ablation, treatment, interventional radiology

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