Мать и дитя в Кузбассе (Jun 2019)
PROBIOTICS AS PREVENTION SARS IN CHILDREN OF EARLY AGE
Abstract
Prevention and treatment of acute respiratory infections during the period of adaptation of children to DOE continues to be relevant. Specific prevention of ARD to create almost impossible, therefore, increasingly resorting to the means of nonspecific preventive maintenance. One of which is the use of probiotics. Aim – reduction in the incidence of acute respiratory viral infections in organized early childhood. Materials and methods. The study included 75 infants attending the nursery, Kindergarten № 239. The main group consisted of 50 children (mean age 28.32 ± 5.65 months).), which in the pre-epidemic period were given a liquid probiotics according to the scheme: during the month 30 minutes before a meal: before dinner «Bifidum BUG» – 3 ml before afternoon tea «Triact» – 3 ml the control group consisted of 25 children (average age of 27.61 ± 6,18 months.). The results of the study and their discussion. The analysis of the obtained clinical and laboratory results allows us to draw conclusions about the positive effect of liquid probiotics «Bifidum BUG» and «Trilact» produced by «Vector-Bialgam» (Novosibirsk) on the health of children. So, after a month of taking probiotics smears on the flora of the nasopharynx recorded a statistically significant decrease in the number of S. аureus in the throat and nose; Str. Mutans, S. epidermidis, Neisseria sicca, Str. Oralis, Str. Mitis in the nasal passages. The strengthening of local immunity is confirmed by a significant decrease in the number of neutrophils, eosinophils in the nasopharyngeal secretion and an increase in the number of cylindrical epithelial cells, an increase in the level of lysozyme and SIgA, a significant decrease or complete disappearance of pathological changes in the nasopharynx of children. All the guys who took «Bifidum BUG» and «Trilact», came the normalization of the gastrointestinal tract. There is a restoration of appetite and the disappearance of constipation, which in young children are associated with a decrease in the amount of bifidoflora. In the study of the dynamics of the program recorded statistically significant reduction in the number of mucus and white blood cells, improvements in the density of feces. Seven times reduced the number of children, bearers of iodophilic flora – the main indicator of the expressed dysbiotic disorders of the intestine. The results of follow-up during the year for children of the main group confirm the preservation of the total immune pool and increased nonspecific resistance of the body. Thus, during the period of SARS disease, there were no manifestations of intoxication, appetite and sleep, sufficient motor activity. In the nasopharynx – light catarrhal manifestations in the form of hyperemia of the pharynx, loose posterior wall, mucous discharge from the nose. The duration of the disease was almost halved, and there were no purulent complications (otitis media and pneumonia). Conclusion. The results indicate the high clinical and microbiological efficacy of probiotic «Bifidum BUG» and «Trilat» NPO «Vector-Bialgam» (Novosibirsk). The main causes of various diseases of children in the period of adaptation to DOW is a meeting with a new microflora and severe stress. All this leads to the suppression of immunity, disruption of adaptive capabilities of the child and, as a result, the emergence and development of the disease. Timely prophylactic administration of probiotic «Bifidum BUG» and «Trilat» possessing immunostimulating and anti-toxic effect, is able to exert local and systemic anti-inflammatory effect, reduces not only the gastrointestinal but also extraintestinal manifestations of inflammation and gives opportunity to more calmly to adapt the child to visit kindergarten.
