Host receptor-targeted therapeutic approach to counter pathogenic New World mammarenavirus infections

Brady T. Hickerson; Tracy R. Daniels-Wells; Cristian Payes; Lars E. Clark; Pierre V. Candelaria; Kevin W. Bailey; Eric J. Sefing; Samantha Zink; James Ziegenbein; Jonathan Abraham; Gustavo Helguera; Manuel L. Penichet; Brian B. Gowen

doi:10.1038/s41467-021-27949-3

Nature Communications (Jan 2022)

Host receptor-targeted therapeutic approach to counter pathogenic New World mammarenavirus infections

Brady T. Hickerson,
Tracy R. Daniels-Wells,
Cristian Payes,
Lars E. Clark,
Pierre V. Candelaria,
Kevin W. Bailey,
Eric J. Sefing,
Samantha Zink,
James Ziegenbein,
Jonathan Abraham,
Gustavo Helguera,
Manuel L. Penichet,
Brian B. Gowen

Affiliations

Brady T. Hickerson: Department of Animal, Dairy and Veterinary Sciences, Utah State University
Tracy R. Daniels-Wells: Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine at UCLA
Cristian Payes: Instituto de Biología y Medicina Experimental (IBYME CONICET)
Lars E. Clark: Department of Microbiology, Blavatnik Institute, Harvard Medical School
Pierre V. Candelaria: Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine at UCLA
Kevin W. Bailey: Department of Animal, Dairy and Veterinary Sciences, Utah State University
Eric J. Sefing: Department of Animal, Dairy and Veterinary Sciences, Utah State University
Samantha Zink: Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA)
James Ziegenbein: Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA)
Jonathan Abraham: Department of Microbiology, Blavatnik Institute, Harvard Medical School
Gustavo Helguera: Instituto de Biología y Medicina Experimental (IBYME CONICET)
Manuel L. Penichet: Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine at UCLA
Brian B. Gowen: Department of Animal, Dairy and Veterinary Sciences, Utah State University

DOI: https://doi.org/10.1038/s41467-021-27949-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Five New World mammarenaviruses (NWMs) enter cells via binding to human transferrin receptor 1 (hTfR1). Here, Hickerson et al. show that hTfR1 targeting antibodies partially protect hTfR1-transgenic mice from lethal NWM challenge via competition of anti-hTfR1 antibody and viral glycoprotein for hTfR1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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