Genome-wide study of Almaty region people for a long time living in areas of pesticide contamination

Abstract

The purpose of this study is to analyze the associations of gene polymorphisms involved in the pathogenesis of chronic diseases that develop against the background of the toxic effects of pollutants in the environment. The study sample for the research was a cohort of people who had been exposed to pesticide pollution for a long time, taken from villages in the Almaty region, on the territory of which destroyed warehouses of pesticides prohibited for use were discovered. Analysis were performed using Genome-wide association study (GWAS) method. A total of 297,397 SNPs were analyzed, 6 of which were found to be significantly associated with the negative effects of chronic exposure to pesticides.