Nature Communications (Jan 2018)

Target engagement imaging of PARP inhibitors in small-cell lung cancer

  • Brandon Carney,
  • Susanne Kossatz,
  • Benjamin H. Lok,
  • Valentina Schneeberger,
  • Kishore K. Gangangari,
  • Naga Vara Kishore Pillarsetty,
  • Wolfgang A. Weber,
  • Charles M. Rudin,
  • John T. Poirier,
  • Thomas Reiner

DOI
https://doi.org/10.1038/s41467-017-02096-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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Treatment of small-cell lung cancer remains a challenge due to multiple mechanisms of resistance to current therapies; measuring patient response is crucial in adapting and choosing adequate treatment. Here the authors develop a strategy to visualise in vivo dynamics of a class of widely used PARP inhibitors.