Oftalʹmologiâ (Oct 2017)

MONITORING OF FUNCTIONAL PARAMETERS IN THE PATIENTS WITH EARLY STAGE OF AGE-RELATED MACULAR DEGENERATION

  • I. A. Gndoyan,
  • A. V. Petrayevsky,
  • N. A. Kuznetsova,
  • A. I. Dyatchina

DOI
https://doi.org/10.18008/1816-5095-2017-3-260-267
Journal volume & issue
Vol. 14, no. 3
pp. 260 – 267

Abstract

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Purpose: clinical monitoring of functional parameters in patients with early stage of age-related macular degeneration (AMD) receiving the dietary supplement Retinorm. Patients and methods: clinical monitoring was conducted during 5 months in 40 patients aged 42–75 years with AMD-manifestations in the form of dry drusen and pigment epithelium defects typed as «geographic atrophy». The main group (20 subjects, 35 eyes) received dietary supplement Retinorm (1 capsule 3 times daily for two months with a month break and repeated admission rate, similar to the first). Patients also received instillations of Visomitin® with3 time daily by such mode: using of instillations 2 months, 1 month break, after that — continuation of instillations during 2 months. The control group (20 subjects, 34 eyes) received only Visomitin® instillations 3 times daily by the same scheme as group I. Checking of visual acuity with maximal correction, static computer perimetry, the optical coherent tomography of retina central area, definition of critical flicker frequency (CFF), retinal electrical sensitivity and optic nerve electrical lability were used as the examination methods. Results: Indicated therapy in the main group improved the monitored functional parameters. Increase of uncorrected visual acuity and the best corrected visual acuity, decrease of relative and absolute scotomas amount in central area of the visual field, increasing of CFF (p<0,05) and tendency to increasing of electrical lability (p<0,5) and lowering the threshold electrical sensitivity (p<0,2) were obtained. The changes of the pointed parameters in the control group were irrelevant and unreliable. Conclusions: The findings suggest a positive effect of Retinorm for the neurosensory cells of retina and for metabolism of the crystalline lens, which contributes to the stabilization of the pathological process in AMD and initial senile cataract. Supplement Retinorm can be recommended for widespread use in patients with early stage-AMD especially in the possible association with initial senile cataract.

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