Nature Communications (Apr 2019)
Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies
- Pradeep S. Rajendran,
- Rosemary C. Challis,
- Charless C. Fowlkes,
- Peter Hanna,
- John D. Tompkins,
- Maria C. Jordan,
- Sarah Hiyari,
- Beth A. Gabris-Weber,
- Alon Greenbaum,
- Ken Y. Chan,
- Benjamin E. Deverman,
- Heike Münzberg,
- Jeffrey L. Ardell,
- Guy Salama,
- Viviana Gradinaru,
- Kalyanam Shivkumar
Affiliations
- Pradeep S. Rajendran
- Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine, University of California - Los Angeles (UCLA)
- Rosemary C. Challis
- Division of Biology and Biological Engineering, California Institute of Technology
- Charless C. Fowlkes
- Department of Computer Science, University of California - Irvine
- Peter Hanna
- Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine, University of California - Los Angeles (UCLA)
- John D. Tompkins
- Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine, University of California - Los Angeles (UCLA)
- Maria C. Jordan
- Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine, University of California - Los Angeles (UCLA)
- Sarah Hiyari
- Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine, University of California - Los Angeles (UCLA)
- Beth A. Gabris-Weber
- Department of Cell Biology, University of Pittsburgh
- Alon Greenbaum
- Division of Biology and Biological Engineering, California Institute of Technology
- Ken Y. Chan
- Division of Biology and Biological Engineering, California Institute of Technology
- Benjamin E. Deverman
- Division of Biology and Biological Engineering, California Institute of Technology
- Heike Münzberg
- Neurobiology of Nutrition and Metabolism Department, Louisiana State University
- Jeffrey L. Ardell
- Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine, University of California - Los Angeles (UCLA)
- Guy Salama
- Department of Cell Biology, University of Pittsburgh
- Viviana Gradinaru
- Division of Biology and Biological Engineering, California Institute of Technology
- Kalyanam Shivkumar
- Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine, University of California - Los Angeles (UCLA)
- DOI
- https://doi.org/10.1038/s41467-019-09770-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
The wiring of peripheral neural circuits that regulate heart rate is poorly understood. In this study, authors used tissue clearing for high-resolution characterization of nerves in the heart in 3D and transgenic and novel viral vector approaches to identify peripheral parasympathetic and sympathetic neuronal populations involved in heart rate control in mice.
