Nature Communications (Apr 2020)

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes

  • Muhmmad Omar-Hmeadi,
  • Per-Eric Lund,
  • Nikhil R. Gandasi,
  • Anders Tengholm,
  • Sebastian Barg

DOI
https://doi.org/10.1038/s41467-020-15717-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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Glucagon is elevated Type-2 diabetes, which contributes to poor glucose control in patients with the disease. Here the authors report that secretion of the hormone is controlled by paracrine inhibition, and that resistance of α-cells to somatostatin can explain hyperglucagonemia in type-2 diabetes.