Nature Communications (Jul 2021)

EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer

  • Marita Zoma,
  • Laura Curti,
  • Dheeraj Shinde,
  • Domenico Albino,
  • Abhishek Mitra,
  • Jacopo Sgrignani,
  • Sarah N. Mapelli,
  • Giada Sandrini,
  • Gianluca Civenni,
  • Jessica Merulla,
  • Giovanna Chiorino,
  • Paolo Kunderfranco,
  • Alessia Cacciatore,
  • Aleksandra Kokanovic,
  • Andrea Rinaldi,
  • Andrea Cavalli,
  • Carlo V. Catapano,
  • Giuseppina M. Carbone

Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19


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Although the TMPRSS2-ERG gene fusion is the most common alteration in human prostate cancer, its involvement in disease progression remains unclear. Here, the authors demonstrate that ERG is methylated by Enhancer of zest homolog 2 leading to enhanced transcriptional and oncogenic activity.