A Comparative Study between Infusion of Dexmedetomidine and Infusion of Magnesium Sulfate on Haemodynamic Changes in Laparoscopic Surgeries Under General Anaesthesia – A Prospective, Randomized, Double-Blind Study

Abstract

Background: The study was undertaken to compare between infusion of Dexmedetomidine and infusion of Magnesium sulfate on haemodynamic changes in laparoscopic surgeries under general anaesthesia – a prospective, randomized, double-blind study Materials and Methods: 80 patients of ASA grade I and II of both sexes undergoing elective surgery in SPS Hospitals, Ludhiana. They were randomly divided into two groups of forty each. Group M received Magnesium Sulfate 30mg/kg in 100ml NS over 10 mins as loading dose followed by 10mg/kg/h in NS to make 50ml and given as infusion. Group D received Dexmedetomidine 1mcg/kg in 100ml NS over 10mins as loading dose followed by 0.2mcg/kg/h in NS to make 50ml and given as infusion. Haemodynamic parameters were noted every 5 mins starting from the time when patient was shifted to operating room to initial 30 mins of pneumoperitoneum and thereafter every 10 mins till the time of deflation. Results: Attenuation of haemodynamic response during pneumoperitoneum was better with Dexmedetomidine group. More number of patients were comfortable with sedation score 2 or 3 (Modified Ramsay Sedation Score) while using Dexmedetomidine group for the first 30 mins than Magnesium Sulfate. No significant adverse effects were noted in both groups. Conclusion: Dexmedetomidine infusion even at a dose of 0.2mcg/kg/h provides a better attenuation of haemodynamic changes during pneumoperitoneum than Magnesium Sulfate in Laparoscopic surgeries. Dexmedetomidine also provides a better sedation score in terms of benefits versus side effects in patients.

Keywords

• dexmedetomidine
• magnesium sulfate
• haemodynamic response
• laparoscopic surgeries
• pneumoperitoneum