mSphere of Influence: the Mycobiota in Human Health and Disease

Abstract

ABSTRACT Soo Chan Lee works in the field of medical mycology. In this mSphere of Influence article, he reflects on how “Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis” (Science 336:1314–1317, 2012, https://doi.org/10.1126/science.1221789) by I. D. Iliev, V. A. Funari, K. D. Taylor, Q. Nguyen, et al., “CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi” (Science 359:232–236, 2018, https://doi.org/10.1126/science.aao1503) by I. Leonardi, X. Li, A. Semon, D. Li, et al., and “The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL” (Nature 574:264–267, 2019, https://doi.org/10.1038/s41586-019-1608-2) by B. Aykut, S. Pushalkar, R. Chen, Q. Li, et al. made an impact on him to study medically important fungi by providing a forum to understand the roles of fungal microbiota or mycobiota in human diseases and health.

Keywords

• microbiota
• mycobiome
• mycobiota
• mycology
• pathogenic fungi