Measurement of some immunological Indicators in patients with recurrent oral lichen planus and some viral infections

Abstract

Oral lichen planus(OLP) usually appears in the form of skin lesions with multiple oral symptoms. Research indicates that it may be an autoimmune disease and is believed to be related to some viral infections. aims to determine the level of some immune indicators in patients with OLP and some types of viral infections associated with it. The research also aimed to determine the level of these indicators in patients who suffered from recurrence of the infection. Methods: ELISA technology was used to determine the level of immune indicators, Results the percentage of patients infected with OLP was 48.9%, while those infected with OLP+HCV, OLP+HBsV, and OLP+HSV-1 were 9.4%, 6.2%, and 5.2%, respectively. Some immune indicators are in higher concentrations in females than in males. While there was variation in the levels of some other measured indicators, as they appeared in higher concentrations in patients infected with OLP+HBsV than in other groups, followed by the group of patients infected with OLP+HCV. In the group of patients with OLP, the infection was recurrent at a rate of 93.6%, while the non-recurrence rate was 6.4%. The immune indicators S-IgA, IgG, and C3 each appeared in higher concentrations in non-recurring disease cases, while the rest of the immune indicators appeared in higher concentrations in recurrent cases, and they varied. The levels of these immune indicators in other disease groups under study among those who have recurrence than in the other group. Conclusion: Some immunological indicators are increase in OLP patients and also, in HBsV infections and the disease may be recurrent in same family.

Keywords

• Oral lichen palus OLP, Hepatitis C, Hepatitis B, Herpes Simplex-1 virus, complement C3, Tumor necrosis factor TNF-α.